From: Subject: A Journey Through The World of Pandemic Influenza: Statins and H5N1 Infection Mitigation Date: Sat, 8 Dec 2007 20:39:14 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0010_01C839DA.656327F0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0010_01C839DA.656327F0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://birdflujourney.typepad.com/a_journey_through_the_wor/2007/04/statins_and_h5n.html =EF=BB=BF A Journey Through = The World of Pandemic Influenza: Statins and H5N1 Infection = Mitigation

A = Journey=20 Through The World of Pandemic Influenza

Trying to understand a potential influenza = pandemic=20 and all that a medium to severe pandemic would mean.

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=C2=AB=20 Influenza Pandemic Vaccines | Mai= n |=20 Stretching=20 Our Supply of Tamiflu =C2=BB

April 01, 2007

Statins and H5N1 Infection Mitigation

My husband takes prescription cholesterol lowering medication and = when the=20 news started circulating around the Cyber Flu Community back in the fall = of 2005=20 I sat up and took note.  Statins are ubiquitous in the US since = doctors=20 seem to like to prescribe them at the first hint of cholesterol = elevation.

As this piece from one of the Reveres at EffectMeasure states, the = research=20 is intriguing and logically indicates that statins may be beneficial = should=20 those taking them become infected.  Please be aware that it is = presumed=20 that you must be on them for at least (guess) a month prior to infection = to see=20 the positive (if any) effects, but the benefits may mean the = difference between=20 living and dying.

From EffectMeasure (old site) [They have since moved: New = Site]

Thursday, September 29, 2005

Bird flu and statins 

In an extremely interesting article in the Clinicians Biosecurity = Network=20 Weekly Bulletin (issue of 9/27/05) Borio and Bartlett review a = suggestion of=20 David Fedson, an expert on vaccines (and former Director of Medical = Affairs at=20 Aventis Pasteur), that statins (tradenames Zocor or Lipitor) might be = helpful=20 in preventing serious complications of influenza, perhaps by dampening = the=20 cytokine response.

The statins are widely used and available drugs used to lower = cholesterol.=20 They also have anti-inflammatory activities, perhaps by preventing = activation=20 of the transcription factor NF-kappaB. One mechanism thought to = underlie the=20 virulence of the H5N1 virus is production of a "cytokine storm," an unregulated systemic = inflammatory=20 response that results in a rapidly developing generalized clotting = disorder,=20 hemorrhage, kidney failure and fluid-filled lungs. The phenomenon is = similar=20 to or the same as what is called gram-negative sepsis or septic shock, = a=20 serious complication of bacterial infections that claims 400,000 to = 500,000=20 lives each year in the US and has 50% to 70% mortality. Treatment for = sepsis=20 is a high priority independently of any role for the same or similar = mechanism=20 in influenza.

The idea that statins might be helpful for sepsis or influenza is = based on=20 more than speculation about mechanism. In 2004 Almog et al. = (Circulation, Aug=20 17 2004;110(7):880-885) reported that patients admitted to the = hospital with=20 acute bacterial infections and who were on statins for more than a = month for=20 other reasons had a dramatically reduced incidence of severe sepsis = (19%=20 versus 2.2%) and reduced admission to the Intensive Care Unit (12.2% = vs.=20 3.7%). An interesting point is that patients on statins might be = expected to=20 be at greater risk because they are taking a medication for a = pre-existing=20 medical condition.

Another study (.pdf available free on line here) looked back at the experience of over 700 = patients=20 that were admitted to a hospital for pneumonia. About 100 of them were = also=20 taking statins. Using 30-day mortality as a measure of outcome, the = statin=20 group had about two thirds fewer deaths than the non-statin group = (odds ratio=20 .36, 95% confidence interval .14 - .92).

Borio and Bartlett also report on an article from The Netherlands = by=20 Enserink to appear shortly in Science (hence not available to = me=20 other than through their summary). Enserink examined influenza seasons = between=20 1996 to 2003, and using a database of 60,000 primary care patients = compared=20 those with at least two statin prescriptions in the previous year to = those=20 without. There was a 26% lower risk of pneumonia in the statin group. = Because=20 of the imprecision of the measure of statin use, I would expect the = statin=20 effect to be even greater than reported here.

Borio and Bartlett conclude:

These studies suggest that = statin therapy=20 may ameliorate the course and/or prevent complications of influenza. = In these=20 studies, it appears that all of the people were already receiving = statins when=20 they got infected. Whether statins would be beneficial after the onset = of=20 symptoms is still unknown. However, further investigation is merited. = This is=20 particularly important given the likelihood that vaccines and = antiviral agents=20 will be in short supply during an influenza pandemic, and statins are = widely=20 available and may be produced relatively = inexpensively.

This is extremely interesting work. It is too early to say that=20 prophylactic statin use in a pandemic is a reasonable strategy, but it = is=20 worth considering.

There is also an OTC product, Red Yeast Rice (the base ingredient in = many=20 statins) that is cheap and easily obtained.

The entry on Red Yeast Rice from the Mayo Clinic's = site:

[snip]

Red yeast rice is the product of yeast ( Monascus = purpureus=20 ) grown on rice, and is served as a dietary staple in some Asian=20 countries. It contains several compounds collectively known as = Monacolins,=20 substances known to inhibit cholesterol synthesis. One of these, = "Monacolin K"=20 is a potent inhibitor of HMG-CoA reductase, and is also known as = Mevinolin or=20 Lovastatin (Mevacor=C2=AE, a drug produced by Merck & Co., Inc). =

Red yeast rice extract has been sold as a natural = cholesterol-lowering=20 agent in over the counter supplements, such as Cholestin TM=20 (Pharmanex, Inc). However, there has been legal and industrial = dispute=20 as to whether red yeast rice is a drug or dietary supplement, = involving this=20 manufacturer, the U.S. Food and Drug Administration (FDA) and the=20 pharmaceutical industry (particularly producers of HMG-CoA reductase = inhibitor=20 prescription drugs or "statins").

[snip]

Uses based on scientific evidence

High cholesterol

Since the 1970s, human studies have reported that red yeast lowers = blood=20 levels of total cholesterol, low-density lipoprotein/LDL ("bad = cholesterol"),=20 and triglyceride levels. Other products containing red yeast rice = extract can=20 still be purchased, mostly over the Internet. However, these products = may not=20 be standardized, and effects are not predictable. For lowering = cholesterol,=20 there is better evidence for using prescription drugs such as = lovastatin.

[snip]

Dosing

The below doses are based on scientific research, publications, = traditional=20 use, or expert opinion. Many herbs and supplements have not been = thoroughly=20 tested, and safety and effectiveness may not be proven. Brands may be = made=20 differently, with variable ingredients, even within the same brand. = The below=20 doses may not apply to all products. You should read product labels, = and=20 discuss doses with a qualified healthcare provider before starting = therapy.=20

Adults (18 years and older):

1,200 milligrams of concentrated red yeast powder capsules have = been taken=20 two times per day by mouth with food.

The average consumption of naturally occurring red yeast rice in = Asia has=20 been reported as 14-55 grams per day.

Children (younger than 18 years):

There is not enough scientific evidence to recommend red yeast for=20 children.

Safety

The U.S. Food and Drug Administration does not strictly regulate = herbs and=20 supplements. There is no guarantee of strength, purity or safety of = products,=20 and effects may vary. You should always read product labels. If you = have a=20 medical condition, or are taking other drugs, herbs, or supplements, = you=20 should speak with a qualified healthcare provider before starting a = new=20 therapy. Consult a healthcare provider immediately if you experience = side=20 effects.

Allergies

There is one report of anaphylaxis (a severe allergic reaction) in = a=20 butcher who touched meat containing red yeast.

Side Effects and Warnings

There is limited evidence about the side effects of red yeast. Mild = headache and abdominal discomfort can occur. Side effects may be = similar to=20 those for the prescription drug lovastatin (Mevacor=C2=AE). Heartburn, = gas,=20 bloating, muscle pain or damage, dizziness, asthma, and kidney = problems are=20 possible. People with liver disease should not use red yeast products. =

In theory, red yeast may increase the risk of bleeding. Caution is = advised=20 in patients with bleeding disorders or taking drugs that may increase = the risk=20 of bleeding. Dosing adjustments may be necessary. A metabolite of = Monascus=20 called mycotoxin citrinin (CTN) in fermentation may be harmful.=20

While no one knows if Statins or Red Yeast Rice will have any = beneficial=20 effects on an infection of H5N1 I will be utilizing them as prophylactic = countermeasures for my family, but most especially for my son who is = smack in=20 the middle of the most-at-risk age group for dying from it.  I am = fully=20 cognizant of the risks and downsides.  I have done my homework and = read all=20 of the available information (scant though it is) and made a conscious = and=20 informed decision that the potential benefits outweigh any of = the=20 potential risks.  Should you consider these as options for = yourself I suggest you do the same.  Nothing in life is entirely = risk free,=20 and everything generally comes at some price, the key is knowing enough = to make=20 informed and intelligent decisions.

My plan of attack is to utilize the supplement Red Yeast Rice once a = Pandemic=20 Influenza strain manifests and switch to the prescription Statin once = the virus=20 is in my area.  As can be appreciated, I have a lot more of the OTC = supplement than I have of the prescription medication.  Timing will = be all=20 important.  My thanks to Bannor at PlanForPandemic for the=20 idea of best use of the resources.

SZ

Posted by = SophiaZoe on April=20 01, 2007 at 12:00 PM in Science,=20 What=20 We Can Do For Ourselves | Permalink=20

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.banner-user-photo IMG { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; = MARGIN: 0px; WIDTH: 64px; PADDING-TOP: 0px; HEIGHT: auto; = BORDER-RIGHT-WIDTH: 0px } .content-nav { MARGIN: 10px; TEXT-ALIGN: center } .date-header { CLEAR: both; POSITION: static } .entry-content { CLEAR: both; POSITION: static } .entry { CLEAR: both; MARGIN-BOTTOM: 20px; OVERFLOW: hidden; WIDTH: 100%; = POSITION: static } .trackbacks { CLEAR: both; MARGIN-BOTTOM: 20px; OVERFLOW: hidden; WIDTH: 100%; = POSITION: static } .comments { CLEAR: both; MARGIN-BOTTOM: 20px; OVERFLOW: hidden; WIDTH: 100%; = POSITION: static } .archive { CLEAR: both; MARGIN-BOTTOM: 20px; OVERFLOW: hidden; WIDTH: 100%; = POSITION: static } .entry-content { CLEAR: both; MARGIN: 5px 10px } .trackbacks-info { CLEAR: both; MARGIN: 5px 10px } .trackback-content { CLEAR: both; MARGIN: 5px 10px } .comments-info { CLEAR: both; MARGIN: 5px 10px } .comment-content { CLEAR: both; MARGIN: 5px 10px } .comments-open-content { CLEAR: both; MARGIN: 5px 10px } .comments-closed { CLEAR: both; MARGIN: 5px 10px } .trackbacks-info P { MARGIN-TOP: 5px } .comments-info P { MARGIN-TOP: 5px } .trackbacks-link { FONT-SIZE: 0.8em } .entry-excerpt { CLEAR: both } .entry-body { CLEAR: both } .entry-more-link { CLEAR: both } .entry-more { CLEAR: both } .entry-footer { CLEAR: both; MARGIN: 5px 10px 20px } .trackback-footer { CLEAR: both; MARGIN: 5px 10px 20px } .comment-footer { CLEAR: both; MARGIN: 5px 10px 20px } .comments-open-footer { CLEAR: both; MARGIN: 5px 10px 20px } .archive-content { CLEAR: both; MARGIN: 5px 10px 20px } .entry-footer P { MARGIN-TOP: 0px; MARGIN-BOTTOM: 2px } .comments-open LABEL { DISPLAY: block } #comment-author { WIDTH: 240px } #comment-email { WIDTH: 240px } #comment-url { WIDTH: 240px } #comment-text { WIDTH: 240px } #comment-bake-cookie { MARGIN-LEFT: 0px; VERTICAL-ALIGN: middle } #comment-post { FONT-WEIGHT: bold } IMG.image-full { WIDTH: 100% } .image-thumbnail { FLOAT: left; MARGIN: 0px 10px 10px 0px; WIDTH: 115px } .image-thumbnail IMG { MARGIN: 0px 0px 2px; WIDTH: 115px; HEIGHT: 115px } .module { OVERFLOW: hidden; WIDTH: 100%; POSITION: relative } .module-content { MARGIN: 5px 10px 20px; POSITION: relative } .module-list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .archive-list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .module-list-item { MARGIN-TOP: 5px; MARGIN-BOTTOM: 5px } .archive-list-item { MARGIN-TOP: 5px; MARGIN-BOTTOM: 5px } .module-more { TEXT-ALIGN: right } .module-elsewhere .module-list IMG { VERTICAL-ALIGN: middle } .archive-elsewhere .archive-list IMG { VERTICAL-ALIGN: middle } .module-presence IMG { VERTICAL-ALIGN: middle } .module-powered .module-content { MARGIN-BOTTOM: 10px } .module-photo .module-content { TEXT-ALIGN: center } .module-wishlist .module-content { TEXT-ALIGN: center } .module-calendar .module-content TABLE { WIDTH: 100%; BORDER-COLLAPSE: collapse } .module-calendar .module-content TH { WIDTH: 14%; TEXT-ALIGN: center } .module-calendar .module-content TD { WIDTH: 14%; TEXT-ALIGN: center } .module-category-cloud .module-list { MARGIN-LEFT: 0px; MARGIN-RIGHT: 0px } .module-category-cloud .module-list-item { PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-LEFT: 0px; BACKGROUND: = none transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px = 5px 0px 0px; LINE-HEIGHT: 1.2em; PADDING-TOP: 0px } .module-category-cloud .cloud-weight-1 { FONT-SIZE: 0.9em } .module-category-cloud .cloud-weight-2 { FONT-SIZE: 0.95em } .module-category-cloud .cloud-weight-3 { FONT-SIZE: 1em } .module-category-cloud .cloud-weight-4 { FONT-SIZE: 1.12em } .module-category-cloud .cloud-weight-5 { FONT-SIZE: 1.25em } .module-category-cloud .cloud-weight-6 { FONT-SIZE: 1.37em } .module-category-cloud .cloud-weight-7 { FONT-SIZE: 1.5em } .module-category-cloud .cloud-weight-8 { FONT-SIZE: 1.62em } .module-category-cloud .cloud-weight-9 { FONT-SIZE: 1.75em } .module-category-cloud .cloud-weight-10 { FONT-SIZE: 1.75em } .typelist-plain .module-list { LIST-STYLE-TYPE: none } .typelist-plain .archive-list { LIST-STYLE-TYPE: none } .typelist-plain .module-list-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .typelist-plain .archive-list-item { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BACKGROUND: none transparent = scroll repeat 0% 0%; PADDING-BOTTOM: 0px; PADDING-TOP: 0px } .typelist-thumbnailed { MARGIN: 0px 0px 20px } .typelist-thumbnailed .module-list-item { CLEAR: both; DISPLAY: block; MARGIN: 0px } .typelist-thumbnailed .module-list-item:unknown { CLEAR: both; DISPLAY: block; FONT-SIZE: 0.1em; VISIBILITY: hidden; = LINE-HEIGHT: 0; HEIGHT: 0px; content: " " } .typelist-thumbnailed .module-list-item { DISPLAY: inline-block } * HTML .typelist-thumbnailed .module-list-item { HEIGHT: 1% } .typelist-thumbnailed .module-list-item { DISPLAY: block } .typelist-thumbnail { MIN-WIDTH: 60px; FLOAT: left; MARGIN: 0px 5px 0px 0px; VERTICAL-ALIGN: = middle; WIDTH: auto; TEXT-ALIGN: center } .typelist-thumbnail IMG { MARGIN: 5px } .module-galleries .typelist-thumbnail IMG { WIDTH: 50px } .typelist-description { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: = 0px; PADDING-TOP: 5px } .typelist-no-description { MARGIN: 10px 0px; TEXT-ALIGN: center } .module-featured-photo .module-content { MARGIN: 0px } .module-photo .module-content { MARGIN: 0px } .module-featured-photo IMG { WIDTH: 100% } .module-recent-photos { MARGIN: 0px 0px 15px } .module-recent-photos .module-content { MARGIN: 0px } .module-recent-photos .module-list { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; DISPLAY: block; = PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; HEIGHT: 1%; BORDER-RIGHT-WIDTH: 0px } .module-recent-photos .module-list:unknown { CLEAR: both; DISPLAY: block; FONT-SIZE: 0.1em; VISIBILITY: hidden; = LINE-HEIGHT: 0; HEIGHT: 0px; content: " " } .module-recent-photos .module-list { DISPLAY: inline-block } * HTML .module-recent-photos .module-list { HEIGHT: 1% } .module-recent-photos .module-list { DISPLAY: block } .module-recent-photos .module-list-item { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; DISPLAY: block; = PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: = 0px; HEIGHT: 1%; BORDER-RIGHT-WIDTH: 0px } .module-recent-photos .module-list-item A { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; DISPLAY: block; = PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; BORDER-RIGHT-WIDTH: = 0px } .module-recent-photos .module-list-item IMG { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 60px; PADDING-TOP: 0px; HEIGHT: 60px } .module-mmt-calendar { MARGIN-BOTTOM: 15px } .module-mmt-calendar .module-content { MARGIN: 0px } .module-mmt-calendar .module-header { MARGIN: 0px } .module-mmt-calendar .module-header A { TEXT-DECORATION: none } .module-mmt-calendar TABLE { WIDTH: 100% } .module-mmt-calendar TH { TEXT-ALIGN: left } .module-mmt-calendar TD { VERTICAL-ALIGN: top; WIDTH: 14%; HEIGHT: 75px; TEXT-ALIGN: left } .day-photo { WIDTH: 54px; HEIGHT: 54px } .day-photo A { DISPLAY: block } .day-photo A IMG { WIDTH: 50px; HEIGHT: 50px } ------=_NextPart_000_0010_01C839DA.656327F0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://birdflujourney.typepad.com/a_journey_through_the_wor/styles.css @import url( /.shared/themes/common/base-weblog.css ); A { TEXT-DECORATION: underline } A:link { COLOR: #660099 } A:visited { COLOR: #006699 } A:hover { COLOR: #660099 } A:active { COLOR: #660099 } BODY { FONT-WEIGHT: normal; FONT-SIZE: medium; BACKGROUND: #ffffff; MARGIN: = 0px; COLOR: #003366; LINE-HEIGHT: 150%; FONT-FAMILY: 'Trebuchet MS', = Verdana, sans-serif } #container { POSITION: static } #container-inner { BORDER-TOP: #660099 1px solid; BACKGROUND: #ffffff; POSITION: static } #banner { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BACKGROUND: #ffffff; = BORDER-BOTTOM-WIDTH: 0px; COLOR: #660099; FONT-FAMILY: Georgia, 'Times = New Roman', serif; HEIGHT: 1%; TEXT-ALIGN: center; BORDER-RIGHT-WIDTH: = 0px } #banner-inner { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; PADDING-BOTTOM: 15px; = PADDING-TOP: 15px } #banner A { COLOR: #660099; TEXT-DECORATION: none } #banner-header { FONT-WEIGHT: bold; FONT-SIZE: x-large; MARGIN: 0.25em 0px; FONT-STYLE: = italic } #banner-description { FONT-SIZE: small; MARGIN: 0.25em 0px } #container { WIDTH: 780px } .layout-artistic #alpha { WIDTH: 315px } .layout-calendar #alpha { WIDTH: 315px } .layout-artistic #alpha-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-calendar #alpha-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-timeline #alpha-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-artistic #beta { WIDTH: 465px } .layout-calendar #beta { WIDTH: 465px } .layout-artistic #beta-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-calendar #beta-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-timeline #beta-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } #beta #gamma { MARGIN: 15px 0px; WIDTH: 210px } #beta #delta { MARGIN: 15px 0px; WIDTH: 210px } #beta #gamma-inner { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #beta #delta-inner { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .content-nav { MARGIN-TOP: 0px } .date-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: medium; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 10px; COLOR: #003366; = FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: center; = BORDER-RIGHT-WIDTH: 0px } .trackbacks-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: medium; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 10px; COLOR: #003366; = FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: center; = BORDER-RIGHT-WIDTH: 0px } .comments-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: medium; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 10px; COLOR: #003366; = FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: center; = BORDER-RIGHT-WIDTH: 0px } .comments-open-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: medium; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 10px; COLOR: #003366; = FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: center; = BORDER-RIGHT-WIDTH: 0px } .archive-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: medium; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px 0px 10px; COLOR: #003366; = FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: center; = BORDER-RIGHT-WIDTH: 0px } .entry-header { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 3px; FONT-WEIGHT: bold; FONT-SIZE: = large; PADDING-BOTTOM: 3px; MARGIN: 1px 0px 10px; BORDER-LEFT: #660099 = 1px solid; COLOR: #003366; PADDING-TOP: 3px; BORDER-BOTTOM: #660099 1px = solid; FONT-FAMILY: 'Trebuchet MS', Verdana, sans-serif; TEXT-ALIGN: = center } .entry-header A { FONT-WEIGHT: bold; TEXT-DECORATION: none } .entry-header A:link { COLOR: #003366 } .entry-header A:visited { COLOR: #003366 } .entry-header A:hover { COLOR: #003366 } .entry-header A:active { COLOR: #003366 } .entry-content { MARGIN: 10px 0px } .entry-footer { MARGIN: 10px 0px } .trackbacks-info { MARGIN: 10px 0px } .trackback-content { MARGIN: 10px 0px } .comments-info { MARGIN: 10px 0px } .comment-content { MARGIN: 10px 0px } .comments-open-content { MARGIN: 10px 0px } .comments-open-footer { MARGIN: 10px 0px } .comments-closed { MARGIN: 10px 0px } .archive-content { MARGIN: 10px 0px } .entry-content P { TEXT-ALIGN: left } .entry-footer { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 3px; FONT-SIZE: small; PADDING-BOTTOM: = 3px; MARGIN: 0px 0px 10px; BORDER-LEFT: #660099 1px solid; COLOR: = #660099; LINE-HEIGHT: normal; PADDING-TOP: 3px; BORDER-BOTTOM: #660099 = 1px solid; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', serif; = TEXT-ALIGN: left } .trackback-footer { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 3px; FONT-SIZE: small; PADDING-BOTTOM: = 3px; MARGIN: 0px 0px 10px; BORDER-LEFT: #660099 1px solid; COLOR: = #660099; LINE-HEIGHT: normal; PADDING-TOP: 3px; BORDER-BOTTOM: #660099 = 1px solid; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', serif; = TEXT-ALIGN: left } .comment-footer { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 3px; FONT-SIZE: small; PADDING-BOTTOM: = 3px; MARGIN: 0px 0px 10px; BORDER-LEFT: #660099 1px solid; COLOR: = #660099; LINE-HEIGHT: normal; PADDING-TOP: 3px; BORDER-BOTTOM: #660099 = 1px solid; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', serif; = TEXT-ALIGN: left } #comment-author { WIDTH: 80% } #comment-email { WIDTH: 80% } #comment-url { WIDTH: 80% } #comment-text { WIDTH: 80% } IMG.image-full { WIDTH: 100% } .module-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: small; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 5px 0px; TEXT-TRANSFORM: uppercase; = COLOR: #336600; LINE-HEIGHT: normal; FONT-FAMILY: Georgia, 'Times New = Roman', serif; LETTER-SPACING: 0.3em; TEXT-ALIGN: left; = BORDER-RIGHT-WIDTH: 0px } .module-content { FONT-SIZE: small; MARGIN: 5px 0px 20px; COLOR: #333333; LINE-HEIGHT: = 150%; FONT-FAMILY: Verdana, Arial, sans-serif; TEXT-ALIGN: left } .module-list { MARGIN: 0px } .module-list-item { MARGIN: 10px 0px } .typelist-thumbnailed .module-list-item { MARGIN: 10px 0px } .module IMG { BORDER-RIGHT: #333333 1px solid; BORDER-TOP: #333333 1px solid; = BORDER-LEFT: #333333 1px solid; BORDER-BOTTOM: #333333 1px solid } .module-photo IMG { BORDER-RIGHT: #333333 1px solid; BORDER-TOP: #333333 1px solid; = BORDER-LEFT: #333333 1px solid; BORDER-BOTTOM: #333333 1px solid } .module-photo .module-content { TEXT-ALIGN: left } .module-powered { TEXT-ALIGN: left } .module-calendar .module-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: small; = BORDER-BOTTOM-WIDTH: 0px; TEXT-TRANSFORM: uppercase; COLOR: #336600; = FONT-FAMILY: Georgia, 'Times New Roman', serif; LETTER-SPACING: 0.3em; = TEXT-ALIGN: left; BORDER-RIGHT-WIDTH: 0px } .module-calendar TH { FONT-WEIGHT: normal; TEXT-ALIGN: center } .module-calendar TD { FONT-WEIGHT: normal; TEXT-ALIGN: center } .typelist-thumbnail IMG { MARGIN: 0px } .module-featured-photo { MARGIN-BOTTOM: 5px } .module-featured-photo .module-content IMG { WIDTH: 420px } .module-recent-photos .module-content { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 2px } .module-recent-photos .module-list { MARGIN: 0px } .module-recent-photos .module-list-item { MARGIN: 0px 2px 2px 0px; WIDTH: 70px; HEIGHT: 70px } .module-tipjar-r2 .tipjar-button { FLOAT: left } .layout-moblog1 #alpha { WIDTH: 200px } .layout-moblog1 #alpha-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-moblog1 #beta { WIDTH: 380px } .layout-moblog1 #beta-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: 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Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.brainyquote.com/link/quotebr.js var br=3Ddocument;=0Dbr.writeln("Quote of the = Day
");=0Dbr.writeln("Wonder rather than doubt is the root of all = knowledge.
");=0Dbr.writeln("Abraham Joshua = Heschel");=0Dbr.writeln("
");=0Dbr.writeln("more Famous Quotes");=0D ------=_NextPart_000_0010_01C839DA.656327F0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://s28.sitemeter.com/js/counter.js?site=s28sophiazoe // Copyright (c)2006 Site Meter, Inc.=20 // 0?sString.substring(0, = sString.indexOf("#")):sString; }, =09 isLocalURL:function(sURL) { return (SiteMeter.trimFragment(document.location.href) =3D=3D = SiteMeter.trimFragment(sURL)); }, =09 getReferral:function() { var sRef=3D""; var g_d =3D document; if (typeof(g_frames) !=3D "undefined") if (g_frames) sRef=3Dtop.document.referrer; if ((sRef =3D=3D "") || (sRef =3D=3D "[unknown origin]") || (sRef = =3D=3D "unknown") || (sRef =3D=3D "undefined")) if (document["parent"] !=3D null)=20 if (parent["document"] !=3D null) // ACCESS ERROR HERE! if (parent.document["referrer"] !=3D null)=20 if (typeof(parent.document) =3D=3D "object") sRef=3Dparent.document.referrer;=20 if ((sRef =3D=3D "") || (sRef =3D=3D "[unknown origin]") || (sRef = =3D=3D "unknown") || (sRef =3D=3D "undefined")) if (g_d["referrer"] !=3D null)=20 sRef =3D g_d["referrer"]; 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