From: Subject: A Journey Through The World of Pandemic Influenza: Vitamin D and Pandemic Influenza Date: Sat, 8 Dec 2007 15:51:33 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C839B2.34E7AF60" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C839B2.34E7AF60 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://birdflujourney.typepad.com/a_journey_through_the_wor/2007/04/vitamin_d_and_p.html =EF=BB=BF A Journey Through = The World of Pandemic Influenza: Vitamin D and Pandemic = Influenza

A = Journey=20 Through The World of Pandemic Influenza

Trying to understand a potential influenza = pandemic=20 and all that a medium to severe pandemic would mean.

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3D"My

What We All Must Understand:

  • =E2=80=9CAny community that fails to = prepare, with the=20 expectation that the federal government or, for that matter, even the = state=20 government will come to their rescue at the final moment will be = tragically=20 wrong,=E2=80=9D Michael Leavitt, Secretary of Health and Human=20 Services

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=C2=AB=20 Feel-Good Vaccine | Mai= n |=20 Keeping=20 It Real =C2=BB

April 22, 2007

Vitamin D and Pandemic Influenza

 

First things first:

 

I am not a medical professional. What I have chosen to arm myself and = my=20 family with is based on my own readings and my own evaluations of an = item's=20 efficacy. I do not recommend anyone blindly believe that what I post = here has=20 merit in the prevention or treatment of Pandemic Influenza. Instead, I = hope you=20 will be motivated to do further reading and independent evaluations to = decide if=20 the options are applicable to your situation.

 

Second things second:

 

When it comes to supplements there is a bewildering array of = information=20 available on the internet, some of it good, much of it bad. There are = often=20 conflicting findings; one study will find a supplement to be of benefit = and=20 another will debunk it. When deciding to utilize a substance that we = intend to=20 ingest into our bodies, or give to those we love, we should first strive = to "do=20 no harm". Secondly we must decide if the sought after benefit outweighs = any of=20 the possible/potential harm. Thirdly, we must understand the proper = storage and=20 usage of the supplement. Even the best, most efficacious vitamin or herb = will do=20 little or no good if we don't take it properly.

 

 

Vitamin D

 

One of the major items I have in my arsenal is plain old Vitamin D. = If, and=20 when, an Influenza Pandemic presents itself I will put my family on a = daily=20 maintenance regime of 2,000 IUs in divided doses. When PanFlu hits the = shores of=20 my country I will up the daily dosage to 4,000 IUs.

 

There are a few caveats associated with Vitamin D and influenza=20 prevention/modulation that should be stated upfront. All points are = taken from=20 Wikipedia's entry = on=20 Vitamin D.

  • The recommended daily allowance seems to be far too low to derive = the=20 sought after benefit.
    • The U.S. Dietary=20 Reference Intake for Adequate Intake (AI) of vitamin D for = infants,=20 children and men and women aged 19=E2=80=9350 is 5 micrograms/day = (200 units/day).[11]=20 Adequate intake increases to 10 micrograms/day (400 units/day) for = men and=20 women aged 51=E2=80=9370 and to 15 micrograms/day (600 units/day) = past the age of=20 70.[1]=20
  • There are skin pigmentation absorption issues. The darker your = skin the=20 less Vitamin D you will make from sunlight, thus your risk of being = Vitamin D=20 deficient increase. The strong anecdotal evidence linking vitamin D = deficiency=20 and influenza would suggest that non-whites will suffer a far greater=20 infection and mortality rate than fair skinned people, and therefore = should=20 have greater motivation to look after their levels of intake.=20
  • At latitudes above or below 30=C2=B0 the decreased angle of the = sun during the=20 winter months, shorter days, colder weather, and heavier clothing will = all=20 contribute to an inability of the body producing the desired amount = naturally,=20 thus greatly increasing the risk of Vitamin D deficiency.=20
  • In order to gain the benefit a daily allowance of at=20 least 2,000 IUs are probably required. =

     

 

From Wikipedia's entry=20 on Vitamin D

Vitamin D is a group of fat-soluble prohormones, = the two=20 major forms of which are vitamin D2 (or ergocalciferol) and = vitamin=20 D3 (or cholecalciferol).[1] The = term=20 vitamin D also refers to metabolites and other analogues of these = substances.=20 Vitamin D3 is produced in skin exposed to sunlight, = specifically=20 ultraviolet B radiation.

    =E2=80=A6..

Vitamin D plays an important role in the maintenance of several = organ=20 systems.[2]=20

Vitamin=20 D2: ergocalciferol or calciferol (made from = ergosterol)=20

Vitamin=20 D3: cholecalciferol (made from = 7-dehydrocholesterol in the=20 skin).

Vitamin D2 is derived from fungal and plant sources, and = is not=20 produced by the human body. Vitamin D3 is derived from = animal=20 sources and is made in the skin when 7-dehydrocholesterol reacts with = UVB=20 ultraviolet light at wavelengths between 270=E2=80=93290 nm.[4] = These=20 wavelengths are present in sunlight at sea level when the sun is more = than 45=C2=B0=20 above the horizon, or when the UV index is greater than 3.[5] = Adequate=20 amounts of vitamin D3 can be made in the skin only after = ten to=20 fifteen minutes of sun exposure at least two times per week to the = face, arms,=20 hands, or back without sunscreen. With longer exposure to UVB rays, an = equilibrium is achieved in the skin, and the vitamin simply degrades = as fast=20 as it is generated.[1]=20

 

 

The Vitamin D story as it relates to Influenza infection in humans is = not=20 extensive, however what is available is promising. I can not do the = concept=20 justice in this blog entry, but what I can do is point you to where you = need to=20 go for support of Vitamin D's usage.

 

The=20 ABCs of D

Almost everyone needs more of the sunshine vitamin =

By Deborah Kotz =

Posted 12/10/06 =

A single nutrient that keeps bones = strong,=20 wards off diabetes, and protects against tuberculosis, cancer, colds, = and the=20 flu. Sound too good to be true? There's more: It's free. But you're = almost=20 certainly not getting enough.

    [snip]

Prior to the industrial revolution, humans had no trouble getting = an=20 abundance of the sunshine vitamin; a mere 10 to 15 minutes outdoors at = midday=20 gives the average fair-skinned person 10,000 international units. = That's far=20 above the government's dietary recommendations of 200 IUs a day up to = age 50,=20 400 IUs to age 70, and 600 IUs over 70. But most people nowadays spend = little=20 time outdoors, and food sources such as milk and salmon contain = relatively=20 modest amounts. What's more, the rash of new findings suggests to the = experts=20 that the guidelines are way too low. "There's no one working in the = field who=20 thinks these levels still make sense," says Walter Willett, a = professor of=20 epidemiology and nutrition at Harvard University whose recent studies = have=20 focused on the connection between vitamin D and cancer. =

[snip]

An immune system link might explain why the flu seems to strike = only during=20 the winter. A review of more than 100 studies on vitamin D and = respiratory=20 diseases, published in the current Epidemiology and = Infection, found=20 that low levels probably allow the viruses to penetrate the immune = system.=20 "It's the first comprehensive theory set forth to explain the = seasonality of=20 influenza," says vitamin D expert and lead author John Cannell, = president of=20 the Vitamin D Council and staff psychiatrist at Atascadero State = Hospital in=20 California. What's now needed, he says, is a trial to see if those = exposed to=20 flu viruses are less likely to come down with an infection if they = take=20 supplements.

The possibility intrigues researchers bracing for an outbreak of = avian flu,=20 which quickly kills by triggering an excessive immune response. = Victims often=20 suffocate when an onslaught of disease-fighting cells, known as a = cytokine=20 storm, results in a rapid buildup of fluid in the lungs. Experts think = vitamin=20 D might rev up the part of the immune system that prevents the germs = from=20 gaining entry to cells in the first place. "This puts a damper on the = part of=20 the immune system that releases the cytokine storm," says Michael = Zasloff, an=20 immunologist and vitamin D researcher at Georgetown University in = Washington,=20 D.C. Research shows that the mechanism also seems to protect against = multiple=20 sclerosis and rheumatoid arthritis, in which the immune system attacks = the=20 body's own healthy tissue.

[snip]

How much to take? The government last year suggested that = African-Americans=20 and the elderly might want more than the guidelines suggest, but it = has set=20 2,000 IUs as its ceiling for safety. Most experts think the limit is = too=20 conservative, noting that there's no evidence of toxicity at much = higher doses=20 and that 2,000 IUs is a worthy goal for everybody. Consuming 3 ounces = of tuna,=20 two glasses of milk, and a glass of fortified orange juice will get = you to 500=20 IUs, and a supplement or two will get you the rest.

 

Further reading:

 

Pandemic Flu = Information=20 Discussion Forum thread: Vitamin=20 D

 

Epidemic=20 Influenza And Vitamin D 15 Sep=20 2006   

[snip]

Hope-Simpson had no way of knowing that vitamin D has profound = effects on=20 human immunity, no way of knowing that it increases production of=20 broad-spectrum antimicrobial peptides, peptides that quickly destroy = the=20 influenza virus. We have only recently learned how vitamin D increases = production of antimicrobial peptides while simultaneously preventing = the=20 immune system from releasing too many inflammatory cells, called = chemokines=20 and cytokines, into infected lung tissue.

 

Vitamin=20 D and genomic stability

[snip]

Vitamin D = is also=20 effective in stimulating DNA synthesis in adult alveolar II cells and = provides a=20 novel mechanism of modulation of epithelial cell proliferation in the = context of=20 lung development and repair against injury.

 

Wikipedia's Vitamin D=20 page

[snip]

Active vitamin D hormone also increases the production of cathelicidin, an antimicrobial peptide that is = produced in=20 macrophages triggered by bacteria, viruses, and fungi.[29] Vitamin D deficiency tends = to increase=20 the risk of infections, such as influenza and tuberculosis.

 

As I tell myself everyday: We are not helpless, even in = the face=20 of something as daunting as a severe Influenza Pandemic. =

 

SZ

 

 

Posted by = SophiaZoe on April=20 22, 2007 at 10:24 PM in Opinions=20 on PanFlu Issues, What=20 We Can Do For Ourselves | Permalink=20

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Comments

SZ, Your blog is always an interesting blog to read. AZ

A study on latitude latitude. It suggests 34 degrees can provide = adequate=20 sunlight. It does not appear to take in to account extra clothing = worn.

...model has been developed to evaluate the effect of seasonal and=20 latitudinal changes on the potential of sunlight to initiate cutaneous=20 production of vitamin D3. Human skin or [3 alpha-3H]7-dehydrocholesterol = exposed=20 to sunlight on cloudless days in Boston (42.2 degrees N) from November = through=20 February produced no previtamin D3. In Edmonton (52 degrees N) this = ineffective=20 winter period extended from October through March. Further south (34 = degrees N=20 and 18 degrees N), sunlight effectively photoconverted 7- = dehydrocholesterol to=20 previtamin D3 in the middle of winter. http://jcem.endojournals.org/cgi/content/abstract/67/2/373=

Posted by: AnneZ | April=20 23, 2007 at 12:53 AM

should it indeed prove useful, could we quickly produce it in large=20 quantities ?
How is it produced ?
Should the average flubie=20 stockpile
it now or wait for further research ?

Posted by: gsgs | April=20 23, 2007 at 01:27 AM

http://www3.interscience.wiley.com/cgi-bin/abstract/102530= 291/ABSTRACT?CRETRY=3D1&SRETRY=3D0

Anti-influenza virus activity of crude extract of Ribes nigrum L. =
Yoko M.=20 Knox *, Tatsuo Suzutani, Itsuro Yosida, Masanobu Azuma
Department of = Microbiology, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, = Asahikawa=20 078-8510, Japan

email: Yoko M. Knox (yokoknox@pacbell.net)

*Correspondence to Yoko M. Knox, Department of Microbiology, = Asahikawa=20 Medical College, 2-1-1-1 Midorigaoka-higashi, Asahikawa 078-8510, = Japan


Research Abstract
This experiment was designed to detect the=20 antiviral activities of crude fruit extracts of wild Ribes nigrum L. = (Kurokarin=20 extract) [blackcurrant] against influenza virus types A and B. Kurokarin = extract=20 was prepared as follows: fruits of Ribes nigrum L. were heated at 50 = =C2=B0C in a=20 heating tank, and then ground under anaerobic conditions. The extracts = were=20 centrifuged, and the supernatant fluid was filtered and sterilized by = infrared=20 rays. The crude extract was diluted with Eagle's minimum essential = medium (MEM)=20 and the solution was adjusted to a pH 7.2 with 0.1 N or 1 N NaOH. Proven = anti-influenza virus effects of the extracts were shown. The = concentration of=20 extract required to inhibit the plaque formation of both IVA and IVB by = 50%=20 (IC50) was 3.2 g/mL. Both IVA and IVB were directly inactivated up to = 99% by 10=20 g/mL of the extract at pH 2.8, and 95% to 98% by this dose at pH 7.2. = The growth=20 of IVA in cells treated with 10 and 100 g/mL of the extract for 6 h = after=20 infection was completely suppressed. Virus titres in culture fluids of = the cells=20 treated with 100 g/mL of Kurokarin extract for 1 h at 8 to 9 h after = infection,=20 were completely suppressed, indicating that the extract inhibited the = virus=20 release from the infected cells. Copyright =C2=A9 2003 John Wiley & = Sons, Ltd.=20

Posted by: Tom | April=20 23, 2007 at 07:41 AM

Thank you AnneZ for the additional resource to peruse. I look forward = to=20 reading it as the latitudes seem to be presented with much more = specificity that=20 what I had been able to find.

As you and I briefly discussed once, I believe this to be a critical = and key=20 component in our fight against PanFlu and any additional resources are = greatly=20 appreciated!

For those who may be unfamiliar with AnneZ, she is a long standing = Flubie who=20 can usually be found at www.FluTrackers.com, well worth the time to = visit, and=20 visit often.
----------

gsgs,

You know my answer to your questions. No, we can not supply 6.3+/- = Billion=20 people with Vitamin D supplements. What we can do is inform people that = it is an=20 item worth looking into and perhaps, after personal review, = independantly=20 stockpiling.

I feel this to especially important for non-white individuals and/or = people=20 who live in the further Northern/Southern latitudes.
--------

Tom,

Thank you as well! I look forward to reading the item with the = attention that=20 it deserves. I am especially interested in seeing if I can track down = any In=20 Vivo findings.

SZ

Posted by: SophiaZoe | April=20 23, 2007 at 11:29 AM

OK, made from cod liver oil or lanolin, I found.
0.03g =3D 1000IE = =3D=20 0.689Euro,
1kg lanolin (sheep wool fat) =3D 12 Euro.
So 6 weeks of = D3 for=20 one pandemic wave
cost about $100

Posted by: gsgs | April=20 24, 2007 at 11:13 AM

oops,divide by 10

Posted by: gsgs | April=20 24, 2007 at 11:15 AM

gs,

I just *love* your mind! Wish you could email some of that math = skill.

And, that reminds... I have to order in some Cod Liver Oil. It just = never=20 ends, as I find new "stuff" that may be of benefit, and then "what's=20 enough?"

SZ

Posted by: SophiaZoe | April=20 24, 2007 at 12:07 PM

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PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-three-column-right #beta { WIDTH: 200px } .layout-three-column-right #beta-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .layout-three-column-right #gamma { WIDTH: 200px } .layout-three-column-right #gamma-inner { BORDER-RIGHT: #660099 1px solid; PADDING-RIGHT: 14px; BORDER-TOP: = #660099 1px solid; PADDING-LEFT: 14px; BACKGROUND: #ffffff; = PADDING-BOTTOM: 14px; BORDER-LEFT: #660099 1px solid; PADDING-TOP: 14px; = BORDER-BOTTOM: #660099 1px solid } .module-header { BACKGROUND-COLOR: #cccccc } BODY { BACKGROUND-COLOR: #cccccc } ------=_NextPart_000_0000_01C839B2.34E7AF60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.brainyquote.com/link/quotebr.js var br=3Ddocument;=0Dbr.writeln("Quote of the = Day
");=0Dbr.writeln("Wonder rather than doubt is the root of all = knowledge.
");=0Dbr.writeln("Abraham Joshua = Heschel");=0Dbr.writeln("
");=0Dbr.writeln("more Famous Quotes");=0D ------=_NextPart_000_0000_01C839B2.34E7AF60 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://s28.sitemeter.com/js/counter.js?site=s28sophiazoe // Copyright (c)2006 Site Meter, Inc.=20 // 0?sString.substring(0, = sString.indexOf("#")):sString; }, =09 isLocalURL:function(sURL) { return (SiteMeter.trimFragment(document.location.href) =3D=3D = SiteMeter.trimFragment(sURL)); }, =09 getReferral:function() { var sRef=3D""; var g_d =3D document; if (typeof(g_frames) !=3D "undefined") if (g_frames) sRef=3Dtop.document.referrer; if ((sRef =3D=3D "") || (sRef =3D=3D "[unknown origin]") || (sRef = =3D=3D "unknown") || (sRef =3D=3D "undefined")) if (document["parent"] !=3D null)=20 if (parent["document"] !=3D null) // ACCESS ERROR HERE! if (parent.document["referrer"] !=3D null)=20 if (typeof(parent.document) =3D=3D "object") sRef=3Dparent.document.referrer;=20 if ((sRef =3D=3D "") || (sRef =3D=3D "[unknown origin]") || (sRef = =3D=3D "unknown") || (sRef =3D=3D "undefined")) if (g_d["referrer"] !=3D null)=20 sRef =3D g_d["referrer"]; 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